Tobacco Regulatory Science (R01 Clinical Trial Optional)

A list of program contacts is available on the program website.

Tobacco Regulatory Science (R01 Clinical Trial Optional) provides grants to support biomedical and behavioral research that will provide scientific data to inform regulation of tobacco products to protect public health. Projects may focus on one or more classes of tobacco products and on one or more vulnerable population.

Vulnerable populations include:

• Youth and young adults
• Individuals from lower socioeconomic backgrounds
• Racial/ethnic minorities
• Sexual and gender minorities
• Rural populations
• Individuals who are pregnant or trying to become pregnant
• Military and veterans
• People who are or have been incarcerated
• People with mental health conditions or substance use disorders

Research focus areas include:

• Product Composition and Design - Understanding the chemical constituents in tobacco products and measurement methods across diverse products
• Toxicity - Understanding how tobacco products and changes to tobacco product characteristics affect their potential to cause morbidity and mortality
• Addiction - Understanding the effect of tobacco product characteristics on addiction and abuse liability
• Health Effects - Understanding the short and long term health effects of tobacco products
• Behavior - Understanding the knowledge, attitudes, and behaviors related to tobacco product use and changes in tobacco product characteristics
• Communications - Understanding how to effectively communicate to the public regarding the health effects of tobacco products and nicotine, including media campaigns and digital media
• Marketing Influences - Understanding why people become susceptible to using tobacco products and transitions between experimentation, initiation to regular use, and dual use
• Impact Analysis - Understanding the impacts of potential FDA regulatory actions

Eligible applicants include:

• Higher education institutions
  • Public/state controlled institutions
  • Private institutions
• Nonprofit organizations
  • With 501(c)(3) status
  • Without 501(c)(3) status
  • Native American tribal organizations
  • Faith-based or community-based organizations
  • Regional organizations
• Governments
  • State
  • County
  • City or township
  • Special districts
  • Federally recognized Indian/Native American tribal governments
  • Indian/Native American tribal governments (other than federally recognized)
  • Eligible agencies of the federal government
  • U.S. territory or possession
• Other
  • Independent school districts
  • Public housing authorities
  • Indian housing authorities
  • Non-domestic entities and non-domestic components of U.S. entities
  • Small businesses
  • For-profit organizations

Award ceiling: $500,000 per year
Project period: 5 years

Links to the full announcement, application instructions, and online application process are available through grants.gov.

While not required, potential applicants are encouraged to email a letter of intent to TRSP@nih.gov at least 60 days prior to the application due date. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

This opportunity expires on May 5, 2025.